蛋白名称
C-Jun-amino-terminal kinase-interacting protein 2
免疫原
The antiserum was produced against synthesized peptide derived from human JIP2. AA range:581-630
特异性
JIP-2 Monoclonal Antibody detects endogenous levels of JIP-2 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
MAPK8IP2; IB2; JIP2; PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2
背景
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014],
功能
alternative products:Experimental confirmation may be lacking for some isoforms,function:The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.,similarity:Belongs to the JIP scaffold family.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH3 domain.,subcellular location:Accumulates in cell surface projections.,subunit:Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK, MAPKK7 and MLK2, MLK3 and DLK. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER
