蛋白名称
Centrosomal protein of 57 kDa
免疫原
The antiserum was produced against synthesized peptide derived from human CEP57. AA range:241-290
特异性
CEP57 Monoclonal Antibody detects endogenous levels of CEP57 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
CEP57; KIAA0092; TSP57; Centrosomal protein of 57 kDa; Cep57; FGF2-interacting protein; Testis-specific protein 57; Translokin
背景
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple
功能
function:Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2.,similarity:Belongs to the translokin family.,subcellular location:Associates with microtubules and the centrosome.,subunit:Homodimer. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.,tissue specificity:Ubiquitous.,
