免疫原
The antiserum was produced against synthesized peptide derived from human MYH14. AA range:1051-1100
特异性
MYH14 Monoclonal Antibody detects endogenous levels of MYH14 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
MYH14; KIAA2034; FP17425; Myosin-14; Myosin heavy chain 14; Myosin heavy chain; non-muscle IIc; Non-muscle myosin heavy chain IIc; NMHC II-C
背景
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
功能
disease:Defects in MYH14 are the cause of non-syndromic sensorineural deafness autosomal dominant type 4 (DFNA4) [MIM:600652]. DFNA4 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,domain:The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.,function:Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.,sequence caution:Translation N-terminally extended.,similarity:Contains 1 IQ domain.,similarity:Contains 1 myosin head-like domain.,subunit:Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light cha
