蛋白名称
Sentrin-specific protease 8
免疫原
The antiserum was produced against synthesized peptide derived from human SENP8. AA range:161-210
特异性
SENP8 Monoclonal Antibody detects endogenous levels of SENP8 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
SENP8; DEN1; NEDP1; PRSC2; FKSG8; Sentrin-specific protease 8; Deneddylase-1; NEDD8-specific protease 1; Protease; cysteine 2; Sentrin/SUMO-specific protease SENP8
背景
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
功能
function:Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.,similarity:Belongs to the peptidase C48 family.,tissue specificity:Broadly expressed, with highest levels in kidney and pancreas.,
