蛋白名称
1,25-dihydroxyvitamin D(3) 24-hydroxylase mitochondrial
免疫原
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 24A1. AA range:411-460
特异性
CYP24A1 Monoclonal Antibody detects endogenous levels of CYP24A1 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
CYP24A1; CYP24; 1; 25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24
背景
cytochrome P450 family 24 subfamily A member 1(CYP24A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Calcidiol + NADPH + O(2) = secalciferol + NADP(+) + H(2)O.,catalytic activity:Calcitriol + NADPH + O(2) = calcitetrol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.,similarity:Belongs to the cytochrome P450 family.,
