背景
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain,
catalyzes the electron transfer from reduced cytochrome c to oxygen.This component is a
heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and
multiple structural subunits encoded by nuclear genes.The mitochondrially-encoded
subunits function in electron transfer, and the nuclear-encoded subunits may function in the
regulation and assembly of the complex.This nuclear gene encodes a protein which is not a
structural subunit, but may be essential for the biogenesis of COX formation and may
function in the hydroxylation of heme O, according to the yeast mutant studies.This protein
is predicted to contain 5 transmembrane domains localized in the mitochondrial inner
membrane. Alternative splicing of this gene generates two transcript variants diverging in
the 3' region.
