背景
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine
proteases. The mammalian calpains include ubiquitous, stomach-specific, and musclespecific proteins. The ubiquitous enzymes consist of heterodimers with distinct large,
catalytic subunits associated with a common small, regulatory subunit. This gene encodes
the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional
start sites in the 5' UTR have been reported. Two transcript variants encoding different
isoforms have been found for this gene.
