蛋白名称
Zinc finger protein 638
免疫原
The antiserum was produced against synthesized peptide derived from human ZNF638. AA range:1271-1320
特异性
NP220 Monoclonal Antibody detects endogenous levels of NP220 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
ZNF638; NP220; ZFML; Zinc finger protein 638; Cutaneous T-cell lymphoma-associated antigen se33-1; CTCL-associated antigen se33-1; Nuclear protein 220; Zinc finger matrin-like protein
背景
zinc finger protein 638(ZNF638) Homo sapiens The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],
功能
alternative products:Additional isoforms seem to exist,disease:Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.,function:Binds to cytidine clusters in double-stranded DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 matrin-type zinc finger.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Interacts with FHL2.,
