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货号: YP-mAb-01848
促销价:

产品介绍

反应种属
Human;Mouse;Rat
应用范围
WB
抗体类型
单克隆抗体
基因名称(Gene Name)
LRAT
蛋白名称
Lecithin retinol acyltransferase
分子量(DA)
27kD
免疫原
The antiserum was produced against synthesized peptide derived from human LRAT. AA range:111-160
特异性
LRAT Monoclonal Antibody detects endogenous levels of LRAT protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Monoclonal, Mouse,IgG
稀释比例
Western Blot: 1/500 - 1/2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
LRAT; Lecithin retinol acyltransferase; Phosphatidylcholine--retinol O-acyltransferase
背景
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)(LRAT) Homo sapiens The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014],
功能
catalytic activity:Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding-protein].,disease:Defects in LRAT are a cause of severe early-onset retinal dystrophy (RD) [MIM:604863].,enzyme regulation:Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK).,function:Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde

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