蛋白名称
ETS-related transcription factor Elf-4
免疫原
The antiserum was produced against synthesized peptide derived from human ELF4. AA range:178-227
特异性
Elf-4 Monoclonal Antibody detects endogenous levels of Elf-4 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
ELF4; ELFR; MEF; ETS-related transcription factor Elf-4; E74-like factor 4; Myeloid Elf-1-like factor
背景
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010],
功能
function:Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity.,induction:By ponisterone A in erythroleukemia cells.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,subcellular location:Accumulation into PML nuclear bodies is mediated by PML.,subunit:Interacts via an N-terminal region with the RUNX1 Runt domain. Interacts via its C-terminus with PML; this interaction enhances ELF4 transactivation of the bovine lysozyme gene.,tissue specificity:Abundantly expressed in the placenta and
