免疫原
The antiserum was produced against synthesized peptide derived from human NOL8. AA range:1118-1167
特异性
Nop132 Monoclonal Antibody detects endogenous levels of Nop132 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
NOL8; C9orf34; NOP132; Nucleolar protein 8; Nucleolar protein Nop132
背景
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008],
功能
function:Plays an essential role in the survival of diffuse-type gastric cancer cells. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.,induction:Up-regulated in diffuse-type gastric cancers.,PTM:Phosphorylated.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7.,tissue specificity:Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.,
