蛋白名称
FAS-associated factor 1
免疫原
The antiserum was produced against synthesized peptide derived from human FAF1. AA range:531-580
特异性
FAF1 Monoclonal Antibody detects endogenous levels of FAF1 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
FAF1; UBXD12; UBXN3A; CGI-03; FAS-associated factor 1; hFAF1; UBX domain-containing protein 12; UBX domain-containing protein 3A
背景
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008],
功能
function:Potentiates but cannot initiate FAS-induced apoptosis.,similarity:Contains 1 UBX domain.,subunit:Specifically interacts with the cytoplasmic domain of FAS.,tissue specificity:Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.,
