免疫原
The antiserum was produced against synthesized peptide derived from human Caspase12. AA range:50-99
特异性
Caspase12 Monoclonal Antibody detects endogenous levels of Caspase12 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
CASP12; Inactive caspase-12; CASP-12
背景
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011],
功能
proteolysis, apoptosis, virus-infected cell apoptosis, ER-nuclear signaling pathway, response to unfolded protein, cell death, response to organic substance, regulation of cell death, programmed cell death, death, endoplasmic reticulum unfolded protein response, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of apoptosis, regulation of programmed cell death, response to protein stimulus,apoptosis in response to endoplasmic reticulum stress,
