蛋白名称
Breast cancer metastasis-suppressor 1
免疫原
The antiserum was produced against synthesized peptide derived from human BRMS1. AA range:21-70
特异性
BRMS-1 Monoclonal Antibody detects endogenous levels of BRMS-1 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
BRMS1; Breast cancer metastasis-suppressor 1
背景
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
功能
function:May be a mediator of metastasis suppression in breast carcinoma.,similarity:Belongs to the BRMS1 family.,tissue specificity:Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.,
