蛋白名称
Peroxisome proliferator-activated receptor gamma coactivator 1-alp
免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
稀释比例
WB 1:500-1:2000; ICC/IF 1:200-1:1000; ELISA 1:5000-1:20000
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
PPARGC1A;Peroxisome proliferator-activated receptor gamma coactivator 1-alp;PPARGC1A ;LEM6 ;PGC1 ;PGC1A ;PPARGC1 ;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ;PGC-1-alpha ;PPAR-gamma coactivator 1-alpha ;PPARGC-1-alpha ;Ligand effect modulator 6
背景
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma , which permits the interaction of this protein with multiple transcription factors. This protein can interact with , and regulate the activities of , cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) . It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis , and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure , regulating cellular cholesterol homoeostasis , and the development of obesity. [provided by RefSeq , Jul 2008] ,
功能
Function:Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. ,similarity:Contains 1 RRM (RNA recognition motif) domain. ,subunit:Binds MYBBP1A , which inhibits transcriptional activation by this protein (By similarity) . Interacts with LRPPRC. Homooligomer. ,tissue specificity:Heart , skeletal muscle , liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle , levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. ,
