基因名称(Gene Name)
TMEM41B KIAA0033
蛋白名称
Transmembrane protein 41B
免疫原
Synthesized peptide derived from human TMEM41B. AA range :80-120
特异性
This antibody detects endogenous levels of TMEM41B at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
TMEM41B KIAA0033;Transmembrane protein 41B
功能
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes . Has phospholipid scramblase activity toward cholesterol and phosphatidylserine , as well as phosphatidylethanolamine and phosphatidylcholine . Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly . In addition to autophagy , involved in other processes in which phospholipid scramblase activity is required . Required for normal motor neuron development (By similarity) . ; (Microbial infection) Critical host factor required for infection by human coronviruses SARS-CoV-2 , HCoV-OC43 , HCoV-NL63 , and HCoV-229E , as well as all flaviviruses tested such as Zika virus and Yellow fever virus . Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles .
