反应种属
Human,Mouse,Rat,Bovine
蛋白名称
Transcription factor SOX-9
免疫原
Synthesized peptide derived from human SOX9 AA range: 1-100
特异性
The antibody can specifically recognize human SOX9 protein. In western blotting of SW480 and HepG2 cell lysates, the antibody can label a 60 kDa band corresponding to SOX9.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
稀释比例
IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
SOX9;Transcription factor SOX-9;campomelic dysplasia autosomal sex reversal ;CMD 1 ;CMD1 ;CMPD 1 ;CMPD1 ;SOX 9 ;Sox9 ;SOX9_HUMAN ;SRA 1 ;SRA1 ;SRXX2 ;SRXY10 ;SRY ;sex determining region Y ;box 9 ;campomelic dysplasia autosomal ;SRY ;sex determining region Y ;box 9 ;SRY ;sex determining region Y ;-box 9 ;SRY ;sex-determining region Y ;-box 9 protein ;SRY related HMG box gene 9 ;Transcription factor SOX 9 ;Transcription factor SOX-9 ;transcription factor SOX9
背景
Sox9 is a transcription factor that plays a key role in chondrocyte differentiation and bone development. It is expressed in cartilage , neural crest , kidney and pancreas.
功能
Disease:Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare , often lethal , dominantly inherited , congenital osteochondrodysplasia , associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones , unusually small scapulae , deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate , micrognatia , flat face and hypertelorism are common. Various defects of the ear are often evident , affecting the cochlea , malleus incus , stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. ,Function:Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. ,similarity:Contains 1 HMG box DNA-binding domain. ,
