基因名称(Gene Name)
CTNND1 KIAA0384
免疫原
Synthesized peptide derived from human p120 catenin AA range: 600-700
特异性
The antibody can specifically recognize human p120 catenin protein. In western blotting of Hela, A431 and HEK293 cell lysates, the antibody can label a band with molecular weight around 100~110 kDa.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
稀释比例
IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
CTNND1 KIAA0384;p120 catenin;Cadherin associated Src substRate ;
Cadherin-associated Src substRate ;
CAS ;
Catenin ;
cadherin associated protein ;
delta 1 ;
Catenin delta 1 ;
Catenin delta ;
Catenin delta-1 ;
CTND1_HUMAN ;
CTNND 1 ;
CTNND ;
CTNND1 ;
delta 1 Catenin ;
KIAA0384 ;
p120 ;
P120 CAS ;
p120 catenin ;
P120 CTN ;
p120 ;
cas ;
p120 ;
ctn ;
P120CAS ;
P120CTN
背景
α- Catenin; β- Catenin; γ- catenin and p120 catenin are members of the connexin family and mediate intercellular adhesion together with E-cadherin. P120 catenin binds to the near membrane region of E-cadherin to form a complex , which is stable and closely linked. In lobular breast cancer , E-cadherin deficiency resulted in the accumulation of p120 catenin in the cytoplasm , while in ductal breast cancer , p120 catenin in the membrane decreased and there was no accumulation of p120 catenin in the cytoplasm. Therefore , it can be used to distinguish lobular carcinoma from ductal carcinoma. Studies have shown that p120 catenin in the cytoplasm of gastric and colon cancer is related to poor adhesion of cancer cells.
功能
Alternative products:Experimental confirmation may be lacking for some isoforms ,Disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated. ,Domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted. ,Function:Binds to and inhibits the transcriptional repressor ZBTB33 , which may lead to activation of target genes of the Wnt signaling pathway (By similarity) . May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF , PDGF , CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. ,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress , which enhances wound closure. ,PTM:Phosphorylated. ,similarity:Belongs to the beta-catenin family. ,similarity:Contains 10 ARM repeats. ,subcellular location:Interaction with GLIS2 promotes nuclear translocation. ,subunit:Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin , alpha-catenin , beta-catenin , and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. ,tissue specificity:Expressed in vascular endothelium. ,
