基因名称(Gene Name)
ADC KIAA1945 ODCP
蛋白名称
Arginine decarboxylase (ADC) (ARGDC) (ODC-paralogue) (ODC-p) (Ornithine decarboxylase-like protein)
免疫原
Synthesized peptide derived from human ADC. AA range:157-227
特异性
This antibody detects endogenous levels of ADC at Human, Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1 , OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding . Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes , leading to formation of the catalytically active ODC homodimer and restoring polyamine production . Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking .
