基因名称(Gene Name)
ACTR2 ARP2
蛋白名称
Actin-related protein 2 (Actin-like protein 2)
免疫原
Synthesized peptide derived from human ARP2. AA range:1-64
特异性
This antibody detects endogenous levels of ARP2 at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
ATP-binding component of the Arp2/3 complex , a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm , providing the force for cell motility . Seems to contact the pointed end of the daughter actin filament . In podocytes , required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation . In addition to its role in the cytoplasmic cytoskeleton , the Arp2/3 complex also promotes actin polymerization in the nucleus , thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization , leading to drive motility of double-strand breaks (DSBs) .
