基因名称(Gene Name)
H2AFY MACROH2A1
蛋白名称
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Polyclonal, Rabbit,IgG
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription . Nucleosomes wrap and compact DNA into chromatin , limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation , DNA repair , DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones , also called histone code , and nucleosome remodeling. Involved in stable X chromosome inactivation . Inhibits the binding of transcription factors , including NF-kappa-B , and interferes with the activity of remodeling SWI/SNF complexes . Inhibits histone acetylation by EP300 and recruits class I HDACs , which induces a hypoacetylated state of chromatin . ; [Isoform 1]: Binds ADP-ribose and O-acetyl-ADP-ribose , and may be involved in ADP-ribose-mediated chromatin modulation . Increases the expression of genes involved in redox metabolism , including SOD3 . ; [Isoform 2]: Represses SOD3 gene expression.
