基因名称(Gene Name)
NAA10 ARD1 ARD1A TE2
蛋白名称
N-alpha-acetyltransferase 10 (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit)
免疫原
Synthesized peptide derived from human ARD1A. AA range:1-23
特异性
This antibody detects endogenous levels of ARD1A at Human, Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity . Acetylates amino termini that are devoid of initiator methionine . The alpha (N-terminal) acetyltransferase activity may be important for vascular , hematopoietic and neuronal growth and development. Without NAA15 , displays epsilon (internal) acetyltransferase activity towards HIF1A , thereby promoting its degradation . Represses MYLK kinase activity by acetylation , and thus represses tumor cell migration . Acetylates , and stabilizes TSC2 , thereby repressing mTOR activity and suppressing cancer development . Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX . Acetylates HIST1H4A . Acts as a negative regulator of sister chromatid cohesion during mitosis .
