基因名称(Gene Name)
WDR24 C16orf21 JFP7
蛋白名称
WD repeat-containing protein 24
免疫原
Synthesized peptide derived from human WDR24
特异性
This antibody detects endogenous levels of WDR24 at Human, Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway . Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 . In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux .
