基因名称(Gene Name)
HSD17B7 UNQ2563/PRO6243
蛋白名称
3-keto-steroid reductase (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62)
免疫原
Synthesized peptide derived from human HSD17B7
特异性
This antibody detects endogenous levels of HSD17B7 at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis . Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) . Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol . Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation . Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase . ; [Isoform 3]: Does not have enzymatic activities toward E1 and DHT.
