蛋白名称
Dimethylaniline monooxygenase [N-oxide-forming] 5 (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5)
免疫原
Synthesized peptide derived from human FMO5
特异性
This antibody detects endogenous levels of FMO5 at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters . Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive . In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) . Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline . Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity . Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity).
