免疫原
Synthesized peptide derived from human Myeloperoxidase(MPO) AA range: 350-450
特异性
This antibody detects endogenous levels of MPO protein.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Polyclonal, Rabbit,IgG
稀释比例
IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
纯化工艺
This antibody detects endogenous levels of MPO protein.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
功能
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage
