免疫原
Synthesized peptide derived from human COX-2 AA range:500-604
特异性
This antibody detects endogenous levels of COX2
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit IgG1, Kappa
稀释比例
IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
纯化工艺
Recombinant Expression and Affinity purified
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase,
is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue
distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid
biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009],
功能
catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A +
H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per
subunit.,disease:Likely to play a role in inflammatory diseases such as
rheumatoid arthritis.,function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti- inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin
biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase
family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,
