免疫原
Synthesized peptide derived from human CK14 AA range: 400-472
特异性
The antibody can specifically recognize human CK14 protein. In
immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the
antibody specifically labels the basal cell of squamous ep
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Mouse, Monoclonal/IgG2b, kappa
稀释比例
IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
This gene encodes a member of the keratin family, the most diverse group of
intermediate filaments. This gene product, a type I keratin, is usually found as a
heterotetramer with two keratin 5 molecules, a type II keratin. Together they form
the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are
associated with epidermolysis bullosa simplex. At least one pseudogene has
been identified at 17p12-p11. [provided by RefSeq, Jul 2008],
功能
disease:Defects in KRT14 are a cause of epidermolysis bullosa simplex DowlingMeara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal
epidermolysis bullosa characterized by generalized herpetiform blistering, milia
formation, dystrophic nails, and mucous membrane involvement.,disease:Defects
in KRT14 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS)
[MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa
characterized by generalized skin blistering. The phenotype is not fundamentally
distinct from the Dowling-Meara type, althought it is less severe.,disease:Defects
in KRT14 are a cause of epidermolysis bullosa simplex Weber-Cockayne type
(WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis
bullosa characterized by blistering limited to palmar and plantar areas of the
skin.,disease:Defects in KRT14 are the cause of derma
