基因名称(Gene Name)
PDGFRA PDGFR2 RHEPDGFRA
免疫原
Synthesized peptide derived from human PDGFR α . AA range: 300-400
特异性
This antibody detects endogenous levels of PDGFR α protein.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Mouse, Monoclonal/IgG1, kappa
稀释比例
WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
platelet derived growth factor receptor alpha(PDGFRA) Homo sapiens This
gene encodes a cell surface tyrosine kinase receptor for members of the platelet- derived growth factor family. These growth factors are mitogens for cells of
mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a
heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ
development,wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by
RefSeq, Mar 2012],
功能
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB
and PDGFC and plays an essential role in the regulation of embryonic
development, cell proliferation, survival and chemotaxis. Depending on the
context, promotes or inhibits cell proliferation and cell migration. Plays an
important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during
embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in
wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric
