蛋白名称
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
免疫原
Synthesized peptide derived from human Arginase-1 AA range: 200-322
特异性
The antibody can specifically recognize human Arginase-1 protein. In western
blotting of HepG2 cell lysate, the antibody can label a 35 kDa band corresponding
to Arginase-1.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Mouse, Monoclonal/IgG2b, kappa
稀释比例
IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
Arginase-1 is a key enzyme in the urea cycle, which can catalyze the
decomposition of arginine into ornithine and urea. Highly specific expression in
liver tissue, but not in bile duct epithelial cells, hepatic sinusoidal endothelial cells,
Kupffer cells and vascular endothelial cells.
功能
catalytic activity:L-arginine + H(2)O = L-ornithine + urea.,cofactor:Binds 2
manganese ions per subunit.,disease:Defects in ARG1 are the cause of
argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia.
Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is
elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia
occurs. Clinical manifestations include developmental delay, seizures, mental
retardation, hypotonia, ataxia, progressive spastic quadriplegia.,induction:By
arginine or homoarginine.,online information:Arginase entry,pathway:Nitrogen
metabolism; urea cycle; L-ornithine and urea from L-arginine: step
1/1.,similarity:Belongs to the arginase family.,subunit:Homotrimer.,
