基因名称(Gene Name)
CHKA CHK CKI
蛋白名称
Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)
免疫原
Synthesized peptide derived from human Choline Kinase Alpha
特异性
This antibody detects endogenous levels of Choline Kinase Alpha at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis . Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis . Has higher activity with choline . May contribute to tumor cell growth . ; [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation . In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets . Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer . Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets .
