基因名称(Gene Name)
SLC46A1 HCP1 PCFT
蛋白名称
Proton-coupled folate transporter (G21) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
免疫原
Synthesized peptide derived from human HCP1/PCFT
特异性
This antibody detects endogenous levels of HCP1/PCFT at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Proton-coupled folate transporter that mediates folate absorption using an H(+) gradient as a driving force . Catalyzes the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus . Functions at acidic pH via alternate outward- and inward-open conformation states . Protonation of residues in the outward open state primes the protein for transport . Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate . Also able to transport antifolate drugs, such as methotrexate and pemetrexed, which are established treatments for cancer and autoimmune diseases . Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes . Also
