蛋白名称
Epidermal growth factor receptor
免疫原
Synthetic Peptide of EGFR AA range: 300-400
特异性
The antibody detects endogenous EGFR proteins.
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and
50% Glycerol.
来源
Monoclonal, Mouse IgG2a, Kappa
稀释比例
WB 1:1000,ELISA 1:5000-20000
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-
chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
The protein encoded by this gene is a transmembrane glycoprotein that is a
member of the protein kinase superfamily. This protein is a receptor for members
of the epidermal growth factor family. EGFR is a cell surface protein that binds to
epidermal growth factor. Binding of the protein to a ligand induces receptor
dimerization and tyrosine autophosphorylation and leads to cell proliferation.
Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun
2016],
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine
phosphate.,disease:Defects in EGFR are associated with lung cancer
[MIM:211980].,function:Isoform 2/truncated isoform may act as an
antagonist.,function:Receptor for EGF, but also for other members of the EGF
family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth
factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell
growth and differentiation. Phosphorylates MUC1 in breast cancer cells and
increases the interaction of MUC1 with C-SRC and CTNNB1/beta-
catenin.,miscellaneous:Binding of EGF to the receptor leads to dimerization,
internalization of the EGF-receptor complex, induction of the tyrosine kinase
activity, stimulation of cell DNA synthesis, and cell proliferation.,online
information:EGFR entry,PTM:Monoubiquitinated and polyubiquitinated upon EGF
stimu
