蛋白名称
Transmembrane protein 175
免疫原
Synthesized peptide derived from human TMEM175
特异性
This antibody detects endogenous levels of TMEM175 at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes . Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion . Constitutes the major lysosomal potassium channel . Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors . The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation . The lysoK(GF) complex is required to protect neurons against stress-induced damage .
