Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199) Rabbit pAb

Human,Mouse,Rat

WB,IHC-P,ICC/IF

多克隆抗体

PIK3R1

Calculated MW: 84 kDa; Observed MW: 55,85 kDa

The antiserum was produced against synthesized peptide derived from human PI3-kinase p85-alpha/gamma around the phosphorylation site of Tyr467/199.

WB: 1/500-1/1000 IF: 1/50-1/200 IHC: 1/50-1/100

1 mg/ml

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

GRB 1;GRB1;p85 alpha;p85;P85A_HUMAN;Phosphatidylinositol 3 kinase associated p 85 alpha;Phosphatidylinositol 3 kinase regulatory 1;Phosphatidylinositol 3 kinase regulatory subunit alpha;Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha);Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;Phosphatidylinositol 3-kinase regulatory subunit alpha;Phosphoinositide 3 kinase regulatory subunit 1 (alpha);Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha);Phosphoinositide 3 kinase regulatory subunit 1;Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha);PI3 kinase p85 subunit alpha;PI3-kinase regulatory subunit alpha;PI3-kinase subunit p85-alpha;PI3K;PI3K regulatory subunit alpha;Pik3r1;PtdIns 3 kinase p85 alpha;PtdIns-3-kinase regulatory subunit alpha;PtdIns-3-kinase regulatory subunit p85-alpha;DKFZp686P5226;FLJ41892;OTTHUMP9783;OTTHUMP9786;p55;p55 gamma;P55G_HUMAN;p55PIK;Phosphatidylinositol 3 kinase regulatory subunit gamma;Phosphatidylinositol 3 kinase regulatory subunit polypeptide 3;Phosphatidylinositol 3 kinase;regulatory subunit;polypeptide 3 (p55;gamma);Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma;Phosphatidylinositol 3-kinase regulatory subunit gamma;Phosphoinositide 3 kinase regulatory subunit 3 (gamma);Phosphoinositide 3 kinase regulatory subunit 3;Phosphoinositide 3 kinase regulatory subunit polypeptide 3;Phosphoinositide 3 kinase;regulatory subunit 3 (p55;PI3 kinase p85 subunit gamma;PI3-kinase regulatory subunit gamma;PI3-kinase subunit p55-gamma;PI3K regulatory subunit gamma;Pik3r3;PtdIns 3 kinase p85 gamma;PtdIns-3-kinase regulatory subunit gamma;PtdIns-3-kinase regulatory subunit p55-gamma

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.