分子量（DA）
Calculated MW: 28 kDa; Observed MW: 28 kDa
免疫原
Recombinant fusion protein containing a sequence of human NR0B2 (NP_068804.1).
稀释比例
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
储存
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
其他名称
NR0B2; SHP; SHP1; nuclear receptor subfamily 0 group B member 2
背景
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
