反应种属
Human;Mouse;Rat;Monkey
蛋白名称
Opioid-binding protein/cell adhesion molecule
免疫原
The antiserum was produced against synthesized peptide derived from human OBCAM. AA range:152-201
特异性
OBCAM Polyclonal Antibody detects endogenous levels of OBCAM protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
OPCML; IGLON1; OBCAM; Opioid-binding protein/cell adhesion molecule; OBCAM; OPCML; Opioid-binding cell adhesion molecule; IgLON family member 1
背景
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
功能
disease:Defects in OPCML are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,function:Binds opioids in the presence of acidic lipids; probably involved in cell contact.,similarity:Belongs to the immunoglobulin superfamily. IgLON family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,
