免疫原
The antiserum was produced against synthesized peptide derived from human MUC13. AA range:421-470
特异性
Mucin 13 Polyclonal Antibody detects endogenous levels of Mucin 13 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
MUC13; DRCC1; RECC; Mucin-13; MUC-13; Down-regulated in colon cancer 1
背景
Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008],
功能
function:Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.,PTM:Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homo-oligomerization into dimers is dependent on intrachain disulfide bonds.,PTM:Highly N-glycosylated.,similarity:Contains 1 SEA domain.,similarity:Contains 3 EGF-like domains.,subcellular location:Also exists as a soluble form.,subunit:Homodimer of beta subunits.,tissue specificity:Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.,
