蛋白名称
Gap junction alpha-3 protein
免疫原
The antiserum was produced against synthesized peptide derived from human GJA3. AA range:151-200
特异性
Connexin 46 Polyclonal Antibody detects endogenous levels of Connexin 46 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
IHC-p 1:100-500;IF/ICC 1:100-500;ELISA 1:5000-20000
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
GJA3; Gap junction alpha-3 protein; Connexin-46; Cx46
背景
The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010],
功能
disease:Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. CZP3 is a form of autosomal dominant congenital cataract.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Alpha-type (group II) subfamily.,subunit:A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.,
