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ATRIP (phospho Ser224) Polyclonal Antibody

货号: YP-Ab-16624
促销价:

产品介绍

反应种属
Human;Rat;Mouse;
应用范围
WB;IHC;IF;ELISA
抗体类型
多克隆抗体
基因名称(Gene Name)
ATRIP
蛋白名称
ATR-interacting protein
分子量(DA)
86kD
免疫原
The antiserum was produced against synthesized peptide derived from human ATRIP around the phosphorylation site of Ser224. AA range:190-239
特异性
Phospho-ATRIP (S224) Polyclonal Antibody detects endogenous levels of ATRIP protein only when phosphorylated at S224.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
ATRIP; AGS1; ATR-interacting protein; ATM and Rad3-related-interacting protein
背景
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012],
功能
caution:The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.,function:Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.,PTM:Phosphorylated by ATR.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the ATRIP family.,subcellular location:Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus).,tissue specificity:Ubiquitous.,

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