蛋白名称
Synaptonemal complex protein 3
免疫原
Purified recombinant human SCP-3 protein fragments expressed in E.coli.
特异性
SCP-3 Monoclonal Antibody detects endogenous levels of SCP-3 protein.
组成
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
稀释比例
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
其他名称
SYCP3; SCP3; Synaptonemal complex protein 3; SCP-3
背景
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010],
功能
disease:Defects in SYCP3 are associated with azoospermia due to perturbations of meiosis [MIM:270960].,function:Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development.,similarity:Belongs to the XLR/SYCP3 family.,subcellular location:In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.,subunit:Interacts with SYCP2.,tissue specificity:Testis-specific.,
