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Nodal Polyclonal Antibody

货号: YP-Ab-16079
促销价:

产品介绍

反应种属
Human;Mouse;Rat
应用范围
WB;IHC;IF;ELISA
抗体类型
多克隆抗体
基因名称(Gene Name)
NODAL
蛋白名称
Nodal homolog
分子量(DA)
40kD
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human NODAL. AA range:294-343
特异性
Nodal Polyclonal Antibody detects endogenous levels of Nodal protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
NODAL; Nodal homolog
背景
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016],
功能
disease:Defects in NODAL may be a cause of situs ambiguus [MIM:601265].,function:Essential for mesoderm formation and axial patterning during embryonic development.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

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