蛋白名称
Insulin-like growth factor-binding protein complex acid labile subunit
免疫原
The antiserum was produced against synthesized peptide derived from human IGFALS. AA range:303-352
特异性
ALS Polyclonal Antibody detects endogenous levels of ALS protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
IGFALS; ALS; Insulin-like growth factor-binding protein complex acid labile subunit; ALS
背景
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
功能
function:Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.,similarity:Contains 20 LRR (leucine-rich) repeats.,subunit:Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.,tissue specificity:Plasma.,
