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Pax-6 Monoclonal Antibody

货号: YP-Ab-15738
促销价:

产品介绍

反应种属
Human
应用范围
WB;FCM;ELISA
抗体类型
单克隆抗体
基因名称(Gene Name)
PAX6
蛋白名称
Paired box protein Pax-6
分子量(DA)
免疫原
Purified recombinant fragment of human Pax-6 expressed in E. Coli.
特异性
Pax-6 Monoclonal Antibody detects endogenous levels of Pax-6 protein.
组成
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
来源
Monoclonal, Mouse
稀释比例
Western Blot: 1/500 - 1/2000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺
Affinity purification
浓度
储存
-20°C/1 year
其他名称
PAX6; AN2; Paired box protein Pax-6; Aniridia type II protein; Oculorhombin
背景
This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015],
功能
developmental stage:Expressed in the developing eye and brain.,disease:Defects in PAX6 are a cause of autosomal dominant keratitis [MIM:148190]. It is an eye disorder characterized by corneal opacification and vascularization, and by foveal hypoplasia.,disease:Defects in PAX6 are a cause of bilateral optic nerve hypoplasia [MIM:165550]; also known as bilateral optic nerve aplasia. Inheritance is autosomal dominant.,disease:Defects in PAX6 are a cause of coloboma of optic nerve [MIM:120430].,disease:Defects in PAX6 are a cause of ectopia pupillae [MIM:129750]. It is a congenital eye malformation in which the pupils are displaced from their normal central position.,disease:Defects in PAX6 are a cause of foveal hypoplasia [MIM:136520]. Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant.,disease:Defects in PAX6 are a cause of Gillespie

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