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Nkx-2.5 Monoclonal Antibody

货号: YP-Ab-15733
促销价:

产品介绍

反应种属
Human
应用范围
WB;ELISA
抗体类型
单克隆抗体
基因名称(Gene Name)
NKX2-5
蛋白名称
Homeobox protein Nkx-2.5
分子量(DA)
37kD
免疫原
Purified recombinant fragment of human Nkx-2.5 expressed in E. Coli.
特异性
Nkx-2.5 Monoclonal Antibody detects endogenous levels of Nkx-2.5 protein.
组成
Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 0.03% sodium azide.
来源
Monoclonal, Mouse
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺
Affinity purification
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
NKX2-5; CSX; NKX2.5; NKX2E; Homeobox protein Nkx-2.5; Cardiac-specific homeobox; Homeobox protein CSX; Homeobox protein NK-2 homolog E
背景
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
功能
disease:Defects in NKX2-5 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.,disease:Defects in NKX2-5 are the cause of atrial septal defect with atrioventricular conduction defects (ASD-AVCD) [MIM:108900]. ASD-AVCD is a congenital heart malformation characterized by atrioventricular conduction defects and incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.,disease:Defects in NKX2-5 are the cause of congenital hypothyroidism non-goitrous type 5 (CHNG5) [MIM:225250]. CHNG5 is a non-autoimmune condition charact

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