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Msx-1 Monoclonal Antibody

货号: YP-Ab-15731
促销价:

产品介绍

反应种属
Human
应用范围
WB;ELISA
抗体类型
单克隆抗体
基因名称(Gene Name)
MSX1
蛋白名称
Homeobox protein MSX-1
分子量(DA)
免疫原
Purified recombinant fragment of human Msx-1 expressed in E. Coli.
特异性
Msx-1 Monoclonal Antibody detects endogenous levels of Msx-1 protein.
组成
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
来源
Monoclonal, Mouse
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺
Affinity purification
浓度
储存
-20°C/1 year
其他名称
MSX1; HOX7; Homeobox protein MSX-1; Homeobox protein Hox-7; Msh homeobox 1-like protein
背景
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008],
功能
disease:A chromosomal aberration involving MSX1 is a cause of Wolf-Hirschhorn syndrome (WHS) [MIM:194190]. WHS is caused by sub-telomeric deletions in the short arm of chromosome 4. WHS is characterized by profound mental retardation, heart defects, and facial clefting.,disease:Defects in MSX1 are a cause of autosomal dominant hypodontia (HYD1) [MIM:106600]; also known as familial or selective tooth agenesis. Absence of less than 6 teeth is referred to as hypodontia. Agenesis of one or more teeth constitutes one of the most common developmental anomalies in man. Reported incidences vary from 1.6% to 9.6%, excluding third molar (Wisdom tooth) agenesis, which occurs in 20% of the population.,disease:Defects in MSX1 are the cause of non-syndromic orofacial cleft type 5 (OFC5) [MIM:608874]; also called non-syndromic cleft lip with or without cleft palate 5. Non-syndromic orofacial cleft is a

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