免疫原
Synthesized peptide derived from human MUC4
特异性
This antibody detects endogenous levels of MUC4 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
IHC-p 1:50. IF 1:50-200
纯化工艺
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
其他名称
Mucin-4 (MUC-4;Ascites sialoglycoprotein;ASGP;Pancreatic adenocarcinoma mucin;Testis mucin;Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1;ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2;ASGP-2)]
功能
alternative products:Additional isoforms exist,developmental stage:Expressed early in the primitive gut before respiratory and digestive epithelial cells have acquired their tissue and cell specificity. Expressed at the basal surface of the epithelium from week 14 to 26 weeks and then predominantly localized in only parietal cells. Immediately before birth, found in the cytoplasm of the mucous columnar epithelial cells. In the embryo expressed in skin, then disappears late in gestation.,function:May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proli
