基因名称(Gene Name)
CLDN18 UNQ778/PRO1572
免疫原
Synthesized peptide derived from human Claudin 18
特异性
The antibody can specifically recognize both human Claudin 18.1 and Claudin 18.2 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.155% sodium azide.
稀释比例
IHC-p 1:100-500, IF 1:100-500
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,tissue specificity:Concentrated at the cell-cell borders of epithelial cells.,
