基因名称(Gene Name)
MAP3K5 ASK1 MAPKKK5 MEKK5
蛋白名称
ASK1 (Phospho Thr838)
免疫原
Synthesized peptide derived from human ASK1 (Phospho Thr838)
特异性
This antibody detects endogenous levels of Human ASK1 (Phospho Thr838)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
其他名称
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25;Apoptosis signal-regulating kinase 1;ASK-1;MAPK/ERK kinase kinase 5;MEK kinase 5;MEKK 5)
背景
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838, inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to, and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.,function:Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.,induction:By TNF-alpha. Inhibited by HIV-1 Nef.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.,tissue specificity:Abundantly expressed in heart and pancreas.,
功能
MAPKKK cascade, activation of MAPK activity, regulation of protein amino acid phosphorylation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, induction of apoptosis,intracellular signaling cascade, protein kinase cascade, JNK cascade, activation of JUN kinase activity, cell death,induction of apoptosis by extracellular signals, regulation of protein kinase cascade, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, death, phosphorylation,regulation of phosphate metabolic process, stress-activated protein kinase signaling pathway, regulation of protein modification process, regulation of cellular protein metabolic process, cellular response to stress, positive regulation of kinase activity, regulation of phosphorylation, regulation of apoptosis, positive regulati
