蛋白名称
Cannabinoid receptor 2
免疫原
The antiserum was produced against synthesized peptide derived from human CNR2. AA range:191-240
特异性
CB2 Polyclonal Antibody detects endogenous levels of CB2 protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
CNR2; Cannabinoid receptor 2; CB-2; CB2; hCB2; CX5
背景
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008],
功能
disease:Allelic variation at the CB2 locus is associated to genetic predisposition for depression in Japanese populations.,function:Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.,PTM:Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localizes to apical dendrite of pyramidal neurons.,tissue specificity:Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood
